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The analgesic ingredient, oxycodone, is really a semi-artificial narcotic with numerous steps qualitatively just like These of morphine; the most well known of such includes the central anxious procedure and organs made up of smooth muscle mass.
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Oxycodone hydrochloride was genotoxic within an in vitro mouse lymphoma assay from the existence of metabolic activation. There was no proof of genotoxic probable within an in vitro bacterial reverse mutation assay (Salmonella typhimurium and Escherichia coli) or within an assay for chromosomal aberrations (in vivo mouse bone marrow micronucleus assay).
A sound administration variety, safeguarded from parenteral abuse and that contains no less than just one viscosity-rising agent In combination with one or more active substances that have parenteral abuse probable.
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Oxycodone hydrochloride is thoroughly metabolized to noroxycodone, oxymorphone, as well as their glucuronides. The main circulating metabolite is noroxycodone with an AUC ratio of 0.
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